Search results for " Diastolic"

showing 10 items of 20 documents

The mitochondria-targeted antioxidant MitoQ modulates oxidative stress, inflammation and leukocyte-endothelium interactions in leukocytes isolated fr…

2016

It is not known if the mitochondria-targeted antioxidants such as mitoquinone (MitoQ) can modulate oxidative stress and leukocyte-endothelium interactions in T2D patients. We aimed to evaluate the beneficial effect of MitoQ on oxidative stress parameters and leukocyte-endothelium interactions in leukocytes of T2D patients. The study population consisted of 98 T2D patients and 71 control subjects. We assessed metabolic and anthropometric parameters, mitochondrial reactive oxygen species (ROS) production, glutathione peroxidase 1 (GPX-1), NFκB-p65, TNFα and leukocyte-endothelium interactions. Diabetic patients exhibited higher weight, BMI, waist circumference, SBP, DBP, glucose, insulin, HOMA…

0301 basic medicineMitochondrial ROSMaleGPX1Antioxidantendocrine system diseasesUbiquinonemedicine.medical_treatmentBMI body mass indexClinical BiochemistryLDL low density lipoprotein cholesterolAnti-Inflammatory AgentsTPP triphenylphosphonium030204 cardiovascular system & hematologyPharmacologymedicine.disease_causeBiochemistryMitoQAntioxidantschemistry.chemical_compound0302 clinical medicineGlutathione Peroxidase GPX1IR insulin resistanceLeukocyteslcsh:QH301-705.5chemistry.chemical_classificationlcsh:R5-920AnthropometryChemistryGlutathione peroxidaseType 2 diabetesMiddle AgedFemalemedicine.symptomlcsh:Medicine (General)Research PaperPMN polymorphonuclear leukocyteshs-CRP high-sensitive C-reactive proteinHOMA-IR homeostasis model assessment of insulin resistanceInflammationT2D type 2 diabetes03 medical and health sciencesOrganophosphorus CompoundsmedicineDBP diastolic blood pressure HbA1c glycated hemoglobinHUVEC human umbilical vein endothelial cellsHumansEndotheliumAgedInflammationReactive oxygen speciesMitoQGlutathione PeroxidaseTumor Necrosis Factor-alphaSBP systolic blood pressureOrganic ChemistryTranscription Factor RelAnutritional and metabolic diseasesHDL high density lipoprotein cholesterolOxidative Stress030104 developmental biologylcsh:Biology (General)Diabetes Mellitus Type 2ImmunologyReactive Oxygen SpeciesOxidative stressRedox Biology
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Motion index: A new parameter to evaluate the diastole by M-Mode imaging

2009

AIM: Heart failure with normal left ventricle (LV) ejection fraction is commonly understood as diastolic heart failure because this expression implies the presence of LV diastolic dysfunction diagnosed by specific echocardiographic findings, such as slow LV relaxation and increased LV stiffness. In this work the authors propose a new parameter named Motion Index, which is measurable by M-Mode technique and it is likely linked to diastolic dysfunction. METHODS: A patient population composed by 134 subjects was enrolled. They all were in New York Heart Association (NYHA) functional class II. Echocardiogram carried out in all patients allowed the authors to distinguish 2 patient arms depending…

AdultHeart Failure DiastolicVentricular Dysfunction LeftPredictive Value of TestsHeart Function TestsMotion IndexHumansStroke VolumeMiddle AgedSensitivity and SpecificityAlgorithmsEchocardiography Doppler Color
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Circulatory response to volume expansion and transjugular intrahepatic portosystemic shunt in refractory ascites: Relationship with diastolic dysfunc…

2015

Abstract Background Cirrhotic cardiomyopathy may lead to heart failure in stressful circumstances, such as after transjugular intrahepatic portosystemic shunt (TIPS) placement. Aim To examine whether acute volume expansion predicts haemodynamic changes after TIPS and elicits signs of impending heart failure. Methods We prospectively evaluated refractory ascites patients (group A) and compensated cirrhotics (group B), who underwent echocardiography, NT-proBNP measurement, and heart catheterization before and after volume load; group A repeated measurements after TIPS. Results 15 patients in group A (80% male; 54 ± 12.4 years) and 8 in group B (100% male; 56 ± 6.2 years) were enrolled. Echoca…

AdultLiver CirrhosisMaleCardiac Catheterizationmedicine.medical_specialtymedicine.medical_treatmentCardiac indexDiastoleElectrocardiographyInternal medicineNatriuretic Peptide BrainmedicineHumansProspective StudiesPulmonary wedge pressureAgedCardiac catheterizationHeart Failure DiastolicHepatologybusiness.industryHemodynamicsGastroenterologyAscitesMiddle Agedmedicine.diseasePeptide Fragmentsmedicine.anatomical_structureEchocardiographySpainHeart failureHeart catheterizationVascular resistanceCardiologyFemaleVascular ResistancePortasystemic Shunt Transjugular IntrahepaticbusinessTransjugular intrahepatic portosystemic shuntDigestive and Liver Disease
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Left ventricular filling abnormalities and obesity-associated hypertension: relationship with overproduction of circulating transforming growth facto…

2005

This study has been designed to evaluate the relationship among transforming growth factor beta1 (TGFbeta1) and some measurements of diastolic function in a population of hypertensive subjects with normal left ventricular ejection fraction. We studied 67 hypertensive outpatients who according to their BMI levels were subdivided into three groups: lean (L), overweight (OW) and obese (OB) hypertensives (HT). Circulating TGFbeta1 and M- and B-mode echocardiography was determined. All hypertensives were further subgrouped, according to European Society of Cardiology Guidelines, into two subsets of patients with normal diastolic function or with diastolic dysfunction. Prevalence of left ventricu…

AdultMalemedicine.medical_specialtySettore MED/09 - Medicina InternaHeart VentriclesEnzyme-Linked Immunosorbent Assayobesity-associated hypertension; TGFb1; left ventricular hypertrophy; left ventricular diastolic functionLeft ventricular hypertrophyTransforming Growth Factor beta1Ventricular Dysfunction LeftDiastoleRisk FactorsTransforming Growth Factor betaVentricule gaucheInternal medicineInternal MedicinemedicineHumansObesityOverproductionAgedbusiness.industryStroke VolumeNutritional statusMiddle Agedmedicine.diseaseMyocardial ContractionSettore MED/11 - Malattie Dell'Apparato CardiovascolareObesityEndocrinologyEchocardiographyHypertensionAdult Aged Biological Markers/blood Diastole Echocardiography Enzyme-Linked Immunosorbent Assay Female Heart Ventricles/physiopathology Heart Ventricles/ultrasonography Humans Hypertension/blood Hypertension/complications* Hypertension/physiopathology Hypertrophy Left Ventricular/blood Hypertrophy Left Ventricular/complications* Hypertrophy Left Ventricular/physiopathology Male Middle Aged Myocardial Contraction/physiology* Obesity/blood Obesity/complications* Obesity/physiopathology Regression Analysis Risk FactorsCardiologyRegression AnalysisFemaleHypertrophy Left VentricularbusinessVentricular fillingBiomarkersTransforming growth factorJournal of Human Hypertension
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Identification of cardiac organ damage in arterial hypertension: insights by echocardiography for a comprehensive assessment

2020

: Arterial hypertension, a widespread disease, whose prevalence increases with age, represents a major risk factor for cardiovascular events, causing damage in several organs, including the heart. In this context, echocardiography has a clear and pivotal role, being able to assess cardiac morphology and detect haemodynamic changes induced by this disease. 2018 European Society of Cardiology/European Society of Hypertension guidelines on AH identified main echo parameters such as left ventricular mass, relative wall thickness and left atrial volume, for detecting cardiac organ damage. The present review highlights the advantage of additional echocardiographic parameters such as diastolic mea…

Aortic valvemedicine.medical_specialtyarterial hypertensionPhysiologyHeart VentriclesDiastoleHemodynamicsContext (language use)Speckle tracking echocardiographyRegurgitation (circulation)030204 cardiovascular system & hematologyarterial hypertension; cardiac organ damage; diastolic dysfunction; echocardiography; left ventricular hypertrophy03 medical and health sciences0302 clinical medicinecardiac organ damageInternal medicineInternal MedicineMedicineHumans030212 general & internal medicineRisk factorbusiness.industrymedicine.diseasePrognosisleft ventricular hypertrophyStenosismedicine.anatomical_structureEchocardiographyAortic ValveHypertensionCardiologydiastolic dysfunctionCardiology and Cardiovascular Medicinebusiness
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Isolated Systolic Hypertension in the Young

2019

Elevated systolic blood pressure with normal diastolic blood pressure is the most prevalent type of hypertension in young people. The prevalence of isolated systolic hypertension reported among youth ranges widely as a result of the differences in population characteristics such as age, ethnicity, and obesity. Even though it is not an unusual condition, there is still debate in the literature about the clinical significance of an isolated increase in systolic blood pressure detected in the first decades of life. The reported phenotypic characteristics of subjects with isolated systolic hypertension are rather scarce and many relevant pieces of information are still elusive. Further studies …

Benign conditionmedicine.medical_specialtyeducation.field_of_studybusiness.industryPopulationmedicine.diseaseObesityBlood pressureElevated systolic blood pressureInternal medicineNormal diastolic blood pressureIsolated systolic hypertensionmedicineCardiologyClinical significanceeducationbusiness
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Left ventricular diastolic function in hypertensives with chronic renal insufficiency.

2006

Left ventricular diastolic function hypertension chronic renal insufficiency.
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Echocardiographic reference ranges for normal cardiac Doppler data: results from the NORRE Study

2015

International audience; AIMS: Reference values for Doppler parameters according to age and gender are recommended for the assessment of heart physiology, specifically for left ventricular (LV) diastolic function. In this study, we report normal reference ranges for Doppler parameters obtained in a large group of healthy volunteers. Echocardiographic data were acquired using state-of-the-art cardiac ultrasound equipment following Doppler acquisition and measurement protocols approved by the European Association of Cardiovascular Imaging. METHODS AND RESULTS: A total of 449 (mean age: 45.8 ± 13.7 years) healthy volunteers (198 men and 251 women) were enrolled at the collaborating institutions…

MaleAgingLeft030204 cardiovascular system & hematologyDoppler echocardiographyVentricular Function LeftNORRE StudyCohort Studies0302 clinical medicineDiastoleReference ValuesNuclear Medicine and ImagingVentricular Function030212 general & internal medicineDoppler echocardiography; NORRE Study; reference values; systolic and diastolic function; Adult; Age Factors; Aged; Aging; Cohort Studies; Diastole; Echocardiography Doppler; Europe; Female; Healthy Volunteers; Heart Ventricles; Humans; Male; Middle Aged; Reference Values; Sex Factors; Systole; Ventricular Function Left; Young Adult; Radiology Nuclear Medicine and Imaging; Cardiology and Cardiovascular Medicinesystolic and diastolic functionmedicine.diagnostic_testDopplerAge FactorsGeneral MedicineMiddle AgedEchocardiography DopplerHealthy VolunteersCardiovascular physiologyEuropemedicine.anatomical_structureEchocardiographyCardiologysymbolsFemale[SDV.IB]Life Sciences [q-bio]/BioengineeringRadiologyCardiology and Cardiovascular MedicineDoppler effectCohort studyAdultmedicine.medical_specialtySystoleHeart VentriclesDiastole03 medical and health sciencessymbols.namesakeYoung AdultSex FactorsInternal medicinemedicineHumansRadiology Nuclear Medicine and imagingSystoleAgedbusiness.industryreference valueDoppler echocardiographyVentricleReference valuesbusiness
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SARS CoV2 infection _The longevity study perspectives

2021

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MaleAgingssRNA single-stranded RNARFLP restriction fragment length polymorphismHSPs heat shock proteinsReviewPTMs post-translational modificationsSevere Acute Respiratory SyndromeBiochemistryHIV-1 human immunodeficiency virus-1TNF-α tumor necrosis factor-αEC endothelial cells0302 clinical medicineFluAV influenza A virusI insertionMedicineIFN-γ interferon-γDIC disseminated intravascular coagulationPCR Polymerase Chain Reactionmedia_commonAged 80 and overLongevityRBD receptor-binding domainNeurologyLongevity modelMI myocardial infarctionNK natural killerhPIV2 human parainfluenza virus type 2media_common.quotation_subjectResearching genetic basis of resistance and potential pharmacological targetsLongevityDBP diastolic blood pressureNF-Kb nuclear transcription factor kBRANTES regulated upon activation normal T cell expressed and secretedMphi human macrophages03 medical and health sciencesCox 2 cyclooxygenase 2ORF open reading framePT prothrombin timeSettore MED/05 - Patologia ClinicaHumansMolecular BiologyInflammatory genesARDS acute respiratory distress syndromeNO nitric oxideD deletionCpGIs CpG islandsT2DM type 2 diabetes mellitusmedicine.diseaseFDP fibrin degradation products030104 developmental biologySARS CoV2 severe acute respiratory syndrome Coronavirus 2 virusImmunologyBMI body max indexItalian nonagenarians/centenariansRSV respiratory syncytial virusComplication030217 neurology & neurosurgeryMAPK mitogen-activated protein kinaseIP-10 IFN-γ -Inducible Protein 1040301 basic medicineAT1R activity of angiotensin 1 receptorsDCs dentritic cellsSSCP single strand conformation polymorphismACE/DD polymorphism of the angiotensin converting enzymeFGF21 fibroblast growth factor 21TLR4 toll-like receptor 4NAD nicotinamide adenine dinucleotideACE angiotensin-I converting enzymeAT2R activity of angiotensin 2 receptorsCOVID-19 Coronavirus disease 2019Respiratory distressACE2 angiotensin converting enzyme 2MKP-1 mitogen-activated protein kinase phosphatase-1 ()PD protease domainSNP single nucleotide polymorphismEH essential hypertensionTNFR tumor necrosis factor receptorINR international normalized ratio of the prothrombin timePAI-1 plasminogen activator inhibitor-1Ang angiotensinLPS lipopolysaccharideMCP1 monocyte chemoattractant protein-1medicine.symptomaPTT partial thromboplastin timeBiotechnologyDUSP1 dual specificity phosphatase 1Coronavirus disease 2019 (COVID-19)PC prostate cancerRAS renin-angiotensin aldosterone systemCCR5Δ32 genetic variant of chemokine receptorCOVID-19 Researching genetic basis of resistance and potential pharmacological targets Italian nonagenarians/centenarians Longevity modelAsymptomaticSARS-1 severe acute respiratory syndrome virus 1SIRT-1 Sirtuin 1Th1 t-helper lymphocyte type 1Immune systemROS reactive oxygen speciesTGF-β transforming growth factor betaET-1 endothelin-1ComputingMethodologies_COMPUTERGRAPHICSADAM-17 metallopeptidase domain 17business.industrySARS-CoV-2SBP systolic blood pressureCOVID-19HDACs histone deacetylasesComorbidityImmune Systembusiness5-LO lipoxygenase 5Ageing Research Reviews
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Diastolic left ventricular function in relation to circulating metabolic biomarkers in a population study

2019

AimsWe studied the association of circulating metabolic biomarkers with asymptomatic left ventricular diastolic dysfunction, a risk-carrying condition that affects 25% of the population.Methods and resultsIn 570 randomly recruited people, we assessed in 2005–2010 and in 2009–2013 the multivariable-adjusted correlations of e’ (early left ventricular relaxation) and E/e’ (left ventricular filling pressure) measured by Doppler echocardiography with 43 serum metabolites, quantified by magnetic resonance spectroscopy. In 2009–2013, e’ cross-sectionally increased (Bonferroni corrected p ≤ 0.016) with the branched-chain amino acid valine (per one standard deviation increment, +0.274 cm/s (95% conf…

MaleCardiac & Cardiovascular SystemsMagnetic Resonance SpectroscopyTime FactorsEpidemiology030204 cardiovascular system & hematologyVentricular Function LeftVentricular Dysfunction Left0302 clinical medicineBelgiumpopulation scienceDiastole030212 general & internal medicinebranched-chain amino acidsMetabolic biomarkersVentricular functionIncidenceMiddle AgedRNA Transfer Amino Acid-SpecificPrognosismetabolomicsEchocardiography DopplerGLUTAMINECardiologyPopulation studyHEART-FAILUREFemalemedicine.symptomCardiology and Cardiovascular MedicineLife Sciences & BiomedicineAdultmedicine.medical_specialtyDiastoleAsymptomatic03 medical and health sciencesPredictive Value of TestsInternal medicineATRIALmedicineHumansAgedScience & Technologybusiness.industryBiomarkerDYSFUNCTIONBiomarker (cell)diastolic left ventricular dysfunctionAsymptomatic DiseasesCardiovascular System & CardiologyLeft ventricular diastolic dysfunctionTransfer RNA AminoacylationbusinessAmino Acids Branched-ChainBiomarkers
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